Dirichlet flow-matching model for protein design that generates family-aware sequences from ancestral-reconstruction priors, not random noise.
University of Tokyo / RIKEN Center for Integrative Medical Sciences / Griffith University / Korea University
Released June 27, 2025
Hierarchical immune cell type annotation for scRNA-seq, rendering expression as images for a CNN. 93.2% mean subtype accuracy over seven datasets.
Tsinghua University / University of Chinese Academy of Sciences / Chinese Academy of Sciences / Peking University / University of Illinois Urbana-Champaign / Griffith University / StoneWise
Released March 6, 2025
Full-atom flow matching model that generates a ligand and the induced-fit holo pocket together, starting from an apo binding site.
Vanderbilt University Medical Center / University of Texas at Austin / Karolinska Institutet / Cleveland Clinic / National Institute of Allergy and Infectious Diseases / Griffith University / University of Washington / Vanderbilt University
Released December 20, 2024
Protein language model that generates paired heavy and light chain human antibodies from an antigen prompt, with binders validated in vitro.
RNA language model trained on multiple sequence alignments of Rfam families, predicting secondary structure and solvent accessibility from homology.