Flatiron Institute

Splice donor and acceptor site prediction from raw DNA, scoring every position of a 20 kb window with an ensemble of dilated residual CNNs.

Isoform-resolved variant effect prediction from DNA sequence, using graph attention over transcript splice structures across 30 human tissues.

Proteome-scale protein dynamics prediction from sequence or structure, predicting residue flexibility, correlations, and conformational states.

Protein-protein interaction language model that embeds whole sets of interacting chains through cross-chain attention, not one sequence at a time.

RNA sequence design model that generates protein-binding RNAs from a target structure alone, growing sequences outward from an anchored seed.

Protein conformational ensemble generation guided by experimental observables, steering a pretrained diffusion sampler toward Boltzmann statistics.

Chromatin-level variant effect prediction from DNA sequence, projecting 21,907 predicted regulatory profiles onto 40 interpretable sequence classes.

RNA-binding protein target site prediction from 1,000 bp of sequence, scoring how a noncoding variant disrupts binding across 88 RBPs.

Tissue-specific gene expression prediction from DNA sequence, scoring a noncoding variant as the log fold change it causes in each of 218 tissues.

Chromatin feature prediction from 2 kb of DNA, scoring 2,002 transcription factor, DNase and histone profiles to rank noncoding variant effects.