East China University of Science and Technology

Zero-shot RNA design pipeline that ranks variants by genomic language model likelihood combined with inverse-folding structural compatibility.

Protein language model pretrained on over nine billion sequences, giving residue embeddings and zero-shot single-site mutant scores from its logits.

Protein conformational ensemble generator that denoises backbone geometry under language-model sequence conditioning with locality-aware attention.

Yeast gene regulatory network model with one pretrained subnetwork per gene, simulating target-gene response to transcription factor perturbation.

Protein expression prediction that pinpoints expression-governing residues by matching a language model landscape against measured fitness data.

Distinguishes experimentally resolved protein structures from predicted ones, pairing a Foldseek 3Di structural language model with a GVP-GNN.

Immunogenicity classifier for reverse vaccinology, fusing frozen protein language model embeddings with Foldseek and ESM3 structure tokens.

Protein language model pairing sequence with quantized local-structure tokens via disentangled attention, for zero-shot variant effect prediction.

Zero-shot variant effect prediction that fuses a frozen protein language model with an equivariant graph network over residue contact graphs.

Protein language model ranking stabilizing mutations with no assay data, trained jointly to predict the growth temperature of each sequence's host.