East China Normal University

Reinforcement-learning generative framework for multi-objective RNA codon optimization that generalizes across six species and five RNA types.

Text-to-protein design retrieving natural protein fragments as a dynamic vocabulary, matching larger baselines on under 0.04% of their training data.

RNA inverse folding model that designs nucleotide sequences for a target 3D backbone by running discrete diffusion in hyperbolic space.

Protein conformational ensemble generator that denoises backbone geometry under language-model sequence conditioning with locality-aware attention.