DP Technology / AI for Science Institute / Shanghai Jiao Tong University / Fudan University
Released August 4, 2025
Molecular reasoning language model for molecule captioning and text-to-molecule generation, trained by chain-of-thought distillation then reward RL.
Organic reaction foundation model that tokenizes 3D molecular structure to predict products, retrosynthetic routes, conditions, and yields.
Institute of Computing Technology, Chinese Academy of Sciences / DP Technology / University of Chinese Academy of Sciences / AI for Science Institute / State Key Laboratory of Medical Proteomics / Peking University
Released June 30, 2025
Proteomics foundation model for peptide-spectrum scoring and open de novo sequencing, reading over 1,300 modifications from tandem mass spectra.
Shanghai Institute of Biochemistry and Cell Biology / Second Military Medical University / DP Technology / Shanghai Jiao Tong University / Tongji University / Zhejiang University School of Medicine / Peking University / University of Chinese Academy of Sciences
Released June 19, 2025
Multimodal drug-response model coupling cell and molecule foundation models, pretrained on 1.8M perturbation RNA-seq profiles over 22,000 compounds.
Protein-ligand binding affinity model that tokenizes quantum electron-cloud density into discrete codes, plus a distilled cloud-free variant.
Autoregressive 3D structure model built on an octree tokenizer, spanning molecule generation, molecular docking, and protein pocket prediction.
Westlake University / Westlake Omics / DP Technology / AI for Science Institute / Peking University
Released February 12, 2025
Neural ODE model of protein network dynamics, pretrained on 38 million perturbed protein measurements for drug efficacy and synergy prediction.
Binding free energy change prediction for antibody mutations, from a lightweight transformer that scores 10,000 variants in under five minutes.
Multimodal contrastive model aligning protein structure and sequence with ligand conformation and graph to retrieve binders without docking.
RNA foundation model trained on 1 billion sequences, with a 400M-parameter variant for secondary and tertiary structure and functional annotation.