Chan Zuckerberg Biohub

Zebrafish sequence-to-function model predicting cell-type-specific gene expression from DNA sequence across embryonic development.

Hierarchical transformer with 1.2 billion parameters that predicts personalized gene expression from diploid genomes for variant effect prediction.

Single-cell transcriptomics foundation model that encodes gene regulatory network structure into self-attention through graph signal processing.

Virtual staining models that translate label-free light microscopy into fluorescent-equivalent predictions of nuclei and plasma membranes.