A U.S. Department of Energy national laboratory near Chicago, applying supercomputing and multidisciplinary science to energy, climate, and biology.
University of Florida / University of Chicago / Toyota Technological Institute at Chicago / Mayo Clinic / Argonne National Laboratory
Released August 18, 2026
Biomolecular sequence-structure co-design that plans over frozen folding and inverse-folding models with Monte Carlo tree search, training nothing.
Stony Brook University / Argonne National Laboratory / University of Chicago / University of Utah
Released June 5, 2025
Generative histopathology foundation model: a diffusion transformer trained on 30M H&E tiles, conditioned on self-supervised slide embeddings.
Learned compression autoencoders for histopathology whole-slide images, tuned so reconstructions preserve the features downstream models rely on.
University of Chicago / Harvard Medical School / University of New South Wales / Garvan Institute of Medical Research / Argonne National Laboratory / National University of Singapore
Released November 14, 2024
Cell-type-specific gene expression prediction from DNA sequence, mapping Enformer epigenomic features to pseudobulk expression for cell-resolved TWAS.
University of Illinois Urbana-Champaign / Argonne National Laboratory
Released February 22, 2023
Protein language model that annotates intrinsically disordered regions per residue from sequence alone, without MSAs or biophysical features.
Genome-scale language model trained on prokaryotic genes and SARS-CoV-2 genomes to model viral evolution and flag emerging variants of concern.