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Multimodal diffusion model that co-designs protein sequence and 3D structure around arbitrary biomolecules, demonstrated by designing novel heme enzymes catalyzing carbene-transfer reactions.

Partially latent flow-matching generative model for de novo atomistic protein binder design against protein and small-molecule targets, with experimental validation at million-design scale.

Partially latent flow-matching model for joint generation of protein amino-acid sequence and full atomistic structure (backbone plus side chains) for proteins up to 800 residues.

All-atom diffusion model for de novo protein design conditioned on ligands, nucleic acids, and arbitrary non-protein atoms, enabling enzyme and DNA binder design.