All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 265–288 of 518 filtered models
SIGMMA
—1—Helmholtz Munich +1 otherNovember 19, 2025contrastive_learningcross_modal_retrievalgene_expression_prediction+7Multi-modal contrastive model that aligns H&E histopathology with spatial transcriptomics across tissue scales to predict gene expression from images.
PathologySpatial omics20OpennessUni-Hema
—1—Information Technology University of the Punjab +1 otherNovember 18, 2025classificationcnnfoundation_model+8Digital hematopathology foundation model unifying blood-cell detection, classification, segmentation, and visual question answering.
Pathology8OpennessMergeDNA
—5—Hierarchical DNA foundation model that co-trains a dynamic token-merging tokenizer with latent Transformers to match genomic information density.
DNA & Gene5OpennessPretrained language model for 3D molecule generation in protein pockets, unifying de novo and fragment-based drug design in one multi-task framework.
Small molecule8OpennessProsit-PTM
411—Spectral prediction model for modified peptides, forecasting fragment-ion intensities and retention time with zero-shot generalization to unseen PTMs.
Protein30OpennessMultimodal conversational LLM for metabolite analysis, fusing a molecular-graph GNN and molecular-image CNN with a Vicuna-13B language backbone.
MetabolomicsSmall molecule48OpennessTEMPO
—5—Chinese University of Hong Kong, Shenzhen +1 otherNovember 7, 2025autoregressiveconformational_ensemble_generationgenerative+4Protein dynamics model that samples conformational ensembles autoregressively at slow and fast timescales, generalizing zero-shot to unseen proteins.
Protein25OpennessEvoSynth
8——Multi-target drug discovery framework pairing a diffusion-transformer generator with evolutionary latent-space search and synthesis-aware scoring.
Small molecule51OpennessAtacformer
28297Transformer foundation model for single-cell ATAC-seq that embeds both cells and cis-regulatory elements for annotation and batch correction.
Single-cellDNA & Gene32OpennessscLDM
587—Latent diffusion model for generating single-cell gene expression profiles, pairing a permutation-invariant autoencoder with a diffusion transformer.
Single-cell75OpennessscLDM.CD4
9—198Single-cell latent diffusion model fine-tuned on 14.5 million CD4+ T cells to simulate transcriptomic effects of single-gene perturbations.
Single-cell75OpennessH3BERTa
1—201Antibody language model pretrained only on CDR-H3 loops, giving embeddings for immune repertoire analysis and antibody sequence classification.
ProteinLanguage model83OpennessVariantFormer
322—Hierarchical transformer with 1.2 billion parameters that predicts personalized gene expression from diploid genomes for variant effect prediction.
DNA & Gene68OpennessGPFM
12954—Hong Kong University of Science and Technology +3 othersNovember 1, 2025cancer_diagnosisfeature_extractionfoundation_model+8Histopathology foundation model extracting general-purpose features from H&E patches by distilling the UNI, Phikon, and CONCH pathology encoders.
Pathology84OpennessPaired heavy/light antibody language model fine-tuning ESM-2 and ESM-C with CDR-preferential masking for zero-shot binding affinity embeddings.
Protein8OpennessMolChord
—2—Structure-based drug design model that generates ligands for a protein pocket, pairing a diffusion structure encoder with preference optimization.
Small moleculeProtein23OpennessStructure-based conformational B-cell epitope predictor that scores local antigen surface patches with ESM-2 embeddings and an ensemble MLP.
Protein12OpennessLSM-MS2
———Foundation model for tandem mass spectrometry that embeds MS/MS spectra into a learned chemical space, resolving isomers and classifying disease.
MetabolomicsSmall molecule4OpennessSiamese protein language model whose embedding distances approximate TM-score and lDDT, enabling alignment-free protein structure comparison.
Protein5OpennessLUNA
131176.3KEEG foundation model whose learned queries map any electrode montage into a fixed latent space, scaling linearly in the number of channels.
Biosignals73Openness- Verily Life SciencesOctober 24, 2025cross_attentiondisease_risk_predictionelectronic_health_records+7
Multimodal EHR foundation model that fuses polygenic risk scores into a GPT-2-style backbone by cross-attention for zero-shot disease risk prediction.
Language modelDNA & Gene8Openness