All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 1–24 of 38 filtered models
PertOmni
—1—Contrastive multimodal model for perturbation screens, aligning transcriptomic signatures with text and cell-painting image embeddings.
Single-cellSmall molecule18OpennessV3Cell
———Xinjiang Technical Institute of Physics and Chemistry +2 othersJune 24, 2026cell_biologydrug_discoverygenerative+4Vision-guided model that builds virtual 3D organoid surrogates from brightfield microscopy to predict chemical perturbation responses without omics.
ImagingPathology4OpennessSelf-supervised 3D masked autoencoder for volumetric fluorescence microscopy, aligned to ESM2 embeddings to predict protein localization.
ImagingSingle-cell71OpennessSingle-cell language model that prepends biomedical knowledge-graph tokens to cell sentences, grounding cell type annotation in pathway structure.
Single-cellLanguage model23OpennessVermeer
3——Generative microscopy foundation model that synthesizes in-silico fluorescence images of protein subcellular localization from amino-acid sequence.
ImagingProtein17OpennessmnDINO
———Vision transformer trained with DINO self-supervision to segment micronuclei in DNA-stained fluorescence images across cell lines and microscopes.
Imaging32OpennessPerturbGen
25——Generative single-cell foundation model trained on 100M+ transcriptomes that predicts how genetic perturbations reshape cell trajectories over time.
Single-cell72OpennessCellPace
———Temporal diffusion framework for single-cell developmental dynamics, interpolating and forecasting cell states from irregularly sampled time series.
Single-cell9OpennessCLM-X
———Hangzhou Institute of Medicine, CASFebruary 18, 2026batch_correctioncell_biologycell_type_annotation+6Multimodal single-cell foundation model whose multiway Transformer jointly models scRNA-seq and scATAC-seq from RNA-only, ATAC-only, or paired inputs.
Single-cell4OpennessProtein language model that encodes sequences as discrete words from a learned vocabulary for zero-shot function inference and protein design.
Protein24OpennessOKR-CELL
———Cross-modal single-cell foundation model that aligns gene-expression profiles with LLM-enriched cell descriptions in a shared embedding space.
Single-cellLanguage model23OpennessMultimodal architecture coupling pretrained DNA, RNA, and protein language models with directional cross-attention into one Virtual Cell Embedding.
DNA & GeneRNAProtein22OpennessSpatialDINO
—1—Native 3D vision transformer self-supervised on unlabeled fluorescence microscopy volumes, segmenting subcellular structures without voxel labels.
Imaging8OpennessscMOBA
———Chinese Academy of Sciences +1 otherDecember 2, 2025cell_biologycell_type_annotationdata_integration+5Conversational single-cell and spatial multi-omics brain foundation model, with zero-shot cell annotation and disease prediction across species.
Single-cellLanguage model5OpennessMicellangelo
———Eindhoven University of TechnologyNovember 24, 2025cell_biologycell_morphology_simulationconditional_generation+5Flow-matching generative model that synthesizes fluorescence images of human fibroblasts conditioned on surface micro-topographies.
Imaging5OpennessMIMYR
—2—Generative framework that reconstructs missing spatial transcriptomics regions by jointly predicting cell locations, cell types, and gene expression.
Spatial omicsSingle-cell16OpennessscLDM
587—Latent diffusion model for generating single-cell gene expression profiles, pairing a permutation-invariant autoencoder with a diffusion transformer.
Single-cell75OpennessscLDM.CD4
9—198Single-cell latent diffusion model fine-tuned on 14.5 million CD4+ T cells to simulate transcriptomic effects of single-gene perturbations.
Single-cell75OpennessBioVERSE
—2—Multimodal biomedical framework aligning frozen single-cell and protein model encoders to an LLM's embedding space for zero-shot reasoning.
Language modelSingle-cellProtein23OpennessrBio
14616—Reasoning language model post-trained on virtual cell simulations, answering questions about gene perturbations and their effects in natural language.
Language model60OpennessCellpose-SAM
2.3K192—Generalist cell segmentation model pairing SAM's ViT-L encoder with Cellpose flow fields, outperforming average human annotators on its benchmark.
Imaging50OpennessCellpose 3
2.3K385—Generalist cell segmentation pairing the cyto3 super-generalist model with one-click networks that denoise, deblur, and upsample microscopy images.
Imaging65Openness