All Competitors

Every biological foundation model, evaluated and ranked by the bio.rodeo team

Showing 124 of 38 filtered models

  • HASSL

    2
    TUM.ai +3 othersJuly 5, 2026cell_biologycontrastive_learningfoundation_model+4

    Hierarchy-aware self-supervised model for single-cell microscopy that preserves morphological structure suppressed by imaging-modality confounders.

    ImagingSingle-cell
    37Openness
  • PertOmni

    1
    Yale University +2 othersJune 26, 2026cell_biologycontrastive_learningdrug_gene_interaction+6

    Contrastive multimodal model for perturbation screens, aligning transcriptomic signatures with text and cell-painting image embeddings.

    Single-cellSmall molecule
    18Openness
  • V3Cell

    Xinjiang Technical Institute of Physics and Chemistry +2 othersJune 24, 2026cell_biologydrug_discoverygenerative+4

    Vision-guided model that builds virtual 3D organoid surrogates from brightfield microscopy to predict chemical perturbation responses without omics.

    ImagingPathology
    4Openness
  • Helmholtz MunichJune 22, 2026cell_biologycontrastive_learningfluorescence_microscopy+6

    Self-supervised 3D masked autoencoder for volumetric fluorescence microscopy, aligned to ESM2 embeddings to predict protein localization.

    ImagingSingle-cell
    71Openness
  • Washington University in St. LouisJune 22, 2026cell_biologycell_type_annotationgene_expression+5

    Single-cell language model that prepends biomedical knowledge-graph tokens to cell sentences, grounding cell type annotation in pathway structure.

    Single-cellLanguage model
    23Openness
  • Vermeer

    3
    Microsoft Research +2 othersJune 1, 2026autoregressivecell_biologyfluorescence_microscopy+7

    Generative microscopy foundation model that synthesizes in-silico fluorescence images of protein subcellular localization from amino-acid sequence.

    ImagingProtein
    17Openness
  • mnDINO

    Morgridge Institute for ResearchMarch 12, 2026cell_biologyfluorescence_microscopyfoundation_model+4

    Vision transformer trained with DINO self-supervision to segment micronuclei in DNA-stained fluorescence images across cell lines and microscopes.

    Imaging
    32Openness
  • PerturbGen

    25
    Wellcome Sanger InstituteMarch 5, 2026cell_biologyfoundation_modelgene_expression+6

    Generative single-cell foundation model trained on 100M+ transcriptomes that predicts how genetic perturbations reshape cell trajectories over time.

    Single-cell
    72Openness
  • CellPace

    McGill UniversityFebruary 26, 2026cell_biologydiffusiongene_expression+5

    Temporal diffusion framework for single-cell developmental dynamics, interpolating and forecasting cell states from irregularly sampled time series.

    Single-cell
    9Openness
  • CLM-X

    Hangzhou Institute of Medicine, CASFebruary 18, 2026batch_correctioncell_biologycell_type_annotation+6

    Multimodal single-cell foundation model whose multiway Transformer jointly models scRNA-seq and scATAC-seq from RNA-only, ATAC-only, or paired inputs.

    Single-cell
    4Openness
  • Tsinghua UniversityFebruary 14, 2026autoregressivecell_biologyde_novo_design+7

    Protein language model that encodes sequences as discrete words from a learned vocabulary for zero-shot function inference and protein design.

    Protein
    24Openness
  • COSMIC

    EPFLJanuary 24, 2026autoencodercell_biologycell_type_annotation+7

    Bidirectional generative framework linking nuclear morphology and gene expression, built on a morphology model trained on 21 million segmented nuclei.

    ImagingSingle-cellSpatial omics
    4Openness
  • OKR-CELL

    BGI ResearchJanuary 9, 2026batch_effect_correctioncell_biologycell_clustering+7

    Cross-modal single-cell foundation model that aligns gene-expression profiles with LLM-enriched cell descriptions in a shared embedding space.

    Single-cellLanguage model
    23Openness
  • Nobuyuki OtaJanuary 3, 2026cell_biologygene_expressiongenomics+4

    Multimodal architecture coupling pretrained DNA, RNA, and protein language models with directional cross-attention into one Virtual Cell Embedding.

    DNA & GeneRNAProtein
    22Openness
  • Harvard Medical SchoolDecember 31, 2025cell_biologyfoundation_modelmicroscopy+5

    Native 3D vision transformer self-supervised on unlabeled fluorescence microscopy volumes, segmenting subcellular structures without voxel labels.

    Imaging
    8Openness
  • scMOBA

    Chinese Academy of Sciences +1 otherDecember 2, 2025cell_biologycell_type_annotationdata_integration+5

    Conversational single-cell and spatial multi-omics brain foundation model, with zero-shot cell annotation and disease prediction across species.

    Single-cellLanguage model
    5Openness
  • Micellangelo

    Eindhoven University of TechnologyNovember 24, 2025cell_biologycell_morphology_simulationconditional_generation+5

    Flow-matching generative model that synthesizes fluorescence images of human fibroblasts conditioned on surface micro-topographies.

    Imaging
    5Openness
  • MIMYR

    2
    Carnegie Mellon UniversityNovember 24, 2025cell_biologycell_type_annotationdata_imputation+6

    Generative framework that reconstructs missing spatial transcriptomics regions by jointly predicting cell locations, cell types, and gene expression.

    Spatial omicsSingle-cell
    16Openness
  • scLDM

    587
    Chan Zuckerberg InitiativeNovember 4, 2025autoencodercell_biologydata_augmentation+8

    Latent diffusion model for generating single-cell gene expression profiles, pairing a permutation-invariant autoencoder with a diffusion transformer.

    Single-cell
    75Openness
  • scLDM.CD4

    9198
    Chan Zuckerberg InitiativeNovember 4, 2025autoencodercell_biologydiffusion+7

    Single-cell latent diffusion model fine-tuned on 14.5 million CD4+ T cells to simulate transcriptomic effects of single-gene perturbations.

    Single-cell
    75Openness
  • BioVERSE

    2
    IBM ResearchOctober 1, 2025cell_biologycell_type_annotationcross_modal_question_answering+5

    Multimodal biomedical framework aligning frozen single-cell and protein model encoders to an LLM's embedding space for zero-shot reasoning.

    Language modelSingle-cellProtein
    23Openness
  • rBio

    14616
    Chan Zuckerberg InitiativeAugust 18, 2025cell_biologyfoundation_modelreinforcement_learning+2

    Reasoning language model post-trained on virtual cell simulations, answering questions about gene perturbations and their effects in natural language.

    Language model
    60Openness
  • Cellpose-SAM

    2.3K192
    HHMI Janelia Research CampusMay 1, 2025cell_biologyfoundation_modelgeneralist_model+4

    Generalist cell segmentation model pairing SAM's ViT-L encoder with Cellpose flow fields, outperforming average human annotators on its benchmark.

    Imaging
    50Openness
  • Cellpose 3

    2.3K385
    HHMI Janelia Research CampusFebruary 1, 2025cell_biologygeneralist_modelimage_restoration+2

    Generalist cell segmentation pairing the cyto3 super-generalist model with one-click networks that denoise, deblur, and upsample microscopy images.

    Imaging
    65Openness