All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 1–24 of 118 filtered models
PlantGeneAnn
12—126Plant genome foundation model for ab initio gene structure annotation, predicting genes, coding sequences, and exons at single-nucleotide resolution.
DNA & Gene66OpennessOmnii
———Genomic language model from Radical Numerics with a 2 Mbp context window, built for zero-shot variant effect prediction and sequence design.
DNA & Gene5OpennessCREP
———Fine-tuned Enformer derivative that annotates cis-regulatory elements from DNA sequence, emitting enhancer, promoter, and insulator class labels.
DNA & Gene8OpennessMethylSeqNet
———University of California, Berkeley +1 otherJune 7, 2026chromatin_accessibility_predictiondna_methylationepigenetics+6Gene regulation model that conditions a pretrained DNA sequence embedding on CpG methylation to capture cell-type and allele-specific regulation.
DNA & Gene18OpennessReCLIP
———University of Chicago +2 othersJune 4, 2026multi_taskprotein_protein_interaction_predictionproteomics+4Transformer that predicts protein-protein interactions at residue resolution, spanning mutations, PTMs, peptide-MHC binding, and disease variants.
Protein22OpennessLDARNet
41—Genomic foundation model with 120M parameters that learns adaptive DNA token boundaries by dynamic chunking, not fixed k-mer or byte-pair tokens.
DNA & Gene26OpennessTESSERA
5——Self-supervised foundation model that embeds cancer genomes from somatic SNVs and copy-number alterations across 33 tumor types for tumor subtyping.
DNA & Gene28OpennessDanioDecima
———Zebrafish sequence-to-function model predicting cell-type-specific gene expression from DNA sequence across embryonic development.
DNA & GeneSingle-cell22OpennessD2D
1——Vrije Universiteit Brussel +1 otherMay 22, 2026binding_region_predictionepistasisintrinsically_disordered_regions+5Variant effect predictor pairing a protein language model with family-specific evolutionary constraints to score stability, binding, and epistasis.
Protein29OpennessGenos-m
26—123Mixture-of-Experts genomic foundation model for the human microbiome, with 4.7B parameters pretrained on bacterial, archaeal, and phage genomes.
DNA & Gene73OpennessProtmRNA
2——Codon-level mRNA language model adapted from ESM-2 650M by swapping amino-acid tokens for codon tokens, transferring protein knowledge to mRNA tasks.
RNA11OpennessDamageFormer
1——Multimodal framework that detects and localizes DNA lesions from native nanopore signal, built on the damage-aware LesionBERT foundation model.
DNA & Gene45OpennessBio-BLIP
———Multimodal Q-former that fuses DNA sequence, gene context, protein function, and text for zero-shot variant interpretation with a frozen LLM.
DNA & GeneLanguage model23OpennessPLM-SAE
———Sparse autoencoders trained on protein language model embeddings to expose interpretable features and drive zero-shot variant effect prediction.
Protein22OpennessENSEMBITS
7——Protein conformational ensemble tokenizer that learns a discrete alphabet of states from molecular dynamics, reusable as a frozen feature layer.
Protein66OpennessOmniGene-4
—1—Unified bio-language Mixture-of-Experts model spanning DNA, protein sequence and structure, and biological text across eight task families.
Language modelDNA & GeneProtein7OpennessProtSent
7—12Protein sequence embedding model, contrastively fine-tuned from ESM-2, that places functionally and structurally related proteins close together.
Protein87OpennessWisteria
———DNA language model combining Mamba state-space layers, gated dilated convolutions, and Fourier attention to capture multi-scale regulatory patterns.
DNA & Gene10Openness- University of KentuckyMay 4, 2026contrastive_learningintrinsic_disorder_predictionmolecular_dynamics+6
Protein language model aligning ESM sequence embeddings with molecular dynamics trajectories for zero-shot mutation effect and stability prediction.
Protein10Openness Carbon
200—6.4KAutoregressive DNA foundation model for variant effect prediction, using 6-mer tokenization to match Evo2-7B win rates at far higher throughput.
DNA & Gene93OpennessMIMIC
37——Generative multimodal foundation model spanning DNA, RNA, and protein, with any-to-any inference across genome, transcriptome, and proteome.
RNAProteinDNA & Gene16OpennessCellPulse
———Direction-aware foundation model trained on bulk RNA-seq differential-expression profiles to simulate coordinated gene dynamics in viral infection.
Single-cellLanguage model4OpennessMach-1
34—Long-context RNA foundation model that predicts splicing, isoform abundance, and variant effects from 64 kb of unspliced pre-mRNA sequence.
RNA39Openness