All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 1–24 of 83 filtered models
tf-SFM
———Specificity Foundation Model that predicts transcription factor-DNA binding specificity from sequence using a physics-derived dual-encoder with symmetric contrastive learning.
DNA & Gene18OpennesscrisprSFM
———Specificity Foundation Model that predicts CRISPR gRNA off-target DNA specificity from sequence using a physics-derived dual-encoder with symmetric contrastive learning.
DNA & Gene19Opennessdrug-SFM
———Specificity Foundation Model that predicts small-molecule drug-target protein specificity from sequence using a physics-derived dual-encoder with symmetric contrastive learning.
Small molecule16Opennessenzyme-SFM
———Specificity Foundation Model that predicts enzyme-substrate specificity from sequence using a physics-derived dual-encoder with symmetric contrastive learning.
Protein23OpennessmhcSFM
———Specificity Foundation Model that predicts peptide-MHC binding specificity from sequence using a physics-derived dual-encoder with symmetric contrastive learning.
Protein23Opennessmir-SFM
———Specificity Foundation Model that predicts microRNA-mRNA target specificity from sequence using a physics-derived dual-encoder with symmetric contrastive learning.
RNA25OpennessTESSERA
5——Self-supervised foundation model that learns reusable representations of cancer genomes from somatic SNVs and copy-number alterations across 33 tumor types.
DNA & Gene28OpennessGenBloom
3——Genetically aligned foundation model for blood smear cytology that links single white-blood-cell morphology to chromosomal aberrations and mutations for AML/APL diagnosis.
Pathology65OpennessC3P
———Contrastive promoter-protein pretraining that aligns bacterial promoters with their encoded proteins to learn regulatory genomics representations.
DNA & Gene77OpennessA self-supervised metabolomic foundation model pretrained on NMR metabolite profiles from 430,000+ UK Biobank participants, applied without backbone retraining to aging, subtyping, and risk tasks.
Metabolomics7OpennessBRIDGE
———The University of Hong KongMay 8, 2026contrastive_learningfoundation_modelgene_expression_prediction+8A multi-organ foundation model aligning histology image features with spatial-transcriptomics gene expression across 13 organs for zero-shot virtual ST and survival prediction.
PathologySpatial omics31OpennessConvergeCELL
——59A virtual cell foundation model pretrained on 23M+ cells from 5,000 patient samples for drug target and biomarker discovery.
Single-cell67OpennessProtSent
6——Contrastively fine-tuned ESM-2 (35M and 150M) protein language models that produce general-purpose sequence embeddings where biological similarity maps to embedding proximity.
Protein87Openness- University of KentuckyMay 4, 2026contrastive_learningintrinsic_disorder_predictionmolecular_dynamics+6
A protein language model that aligns ESM sequence embeddings with molecular-dynamics trajectory embeddings via contrastive learning for zero-shot mutation-effect prediction.
Protein10Openness H2O
———Tencent AI for Life Science Lab +2 othersApril 24, 2026contrastive_learningfoundation_modelgene_expression+6A foundation model that predicts spatial transcriptomics and proteomics directly from routine H&E whole-slide images using a vision transformer aligned with a language model.
PathologySpatial omics7OpennessDIA-CLIP
———AI for Science Institute +1 otherApril 16, 2026contrastive_learningencoder_decoderfoundation_model+6A CLIP-style dual-encoder model that learns a shared peptide-spectrum representation for zero-shot peptide-spectrum-match inference in DIA proteomics.
Protein11OpennessCLOP-DiT
———Generates single-cell transcriptomic profiles from structured biological metadata via contrastive language-omics pretraining and a diffusion transformer.
Single-cell10OpennessCLIPepPI
1——Hebrew University of JerusalemMarch 20, 2026contrastive_learningpeptide_binding_predictionprotein_protein_interaction+5Dual-encoder contrastive model that embeds protein domains and peptides into a shared space to predict domain-peptide binding specificity at proteome scale.
Protein50OpennessSELFormerMM
3——Multimodal molecular foundation model fusing SELFIES sequences, 2D graphs, text descriptions, and knowledge-graph embeddings via contrastive pretraining for property prediction.
Small molecule55OpennessHorizyn-1
111—Dual-encoder contrastive model that retrieves enzymes for query reactions by matching reaction fingerprints to protein sequence embeddings.
ProteinSmall molecule21OpennessGeneralist EEG-to-text foundation model that translates EEG segments into clinically grounded natural-language descriptions via spectro-spatial grounding and state-space reasoning.
Biosignals18OpennessProtAlign
———Lawrence Livermore National LaboratoryMarch 6, 2026contrastive_learningcross_modal_retrievalembeddings+4A contrastive cross-modal encoder that aligns protein sequence (ESM-2) and structure (ProteinMPNN) representations into a shared embedding space for cross-modal retrieval.
Protein35OpennessCALM-1.0
—1—Contrastive antibody language model that predicts antibody-antigen binding specificity directly from amino acid sequence using a dual-encoder, cross-attentive architecture.
Protein10Openness