All Competitors
Every biological foundation model, evaluated and ranked by the bio.rodeo team
Showing 1–24 of 105 filtered models
WattmaMod
———RNA modification profiling from nanopore direct RNA-seq signal; self-supervised pretraining resolves 11 modification types and extends to new ones.
RNABiosignals21OpennessHistopathology-to-molecular alignment model that queries H&E slides with gene-set signatures to predict pathway activity without sequencing.
PathologyRNA16OpennessPertOmni
—1—Contrastive multimodal model for perturbation screens, aligning transcriptomic signatures with text and cell-painting image embeddings.
Single-cellSmall molecule18OpennessSelf-supervised 3D masked autoencoder for volumetric fluorescence microscopy, aligned to ESM2 embeddings to predict protein localization.
ImagingSingle-cell71OpennessvBx-1.0
———Multimodal foundation model for precision neurology that reconstructs a patient's molecular brain state from blood to predict disease progression.
Single-cellDNA & Gene5OpennessSpineAgent
6——Multi-sequence spine MRI foundation model with DINOv3 encoders, supporting condition classification, pathology localization, and report generation.
Imaging55Opennesstf-SFM
—2—Transcription factor-DNA binding specificity prediction from sequence, with a physics-derived dual-encoder trained by symmetric contrastive learning.
DNA & Gene18Opennessdrug-SFM
—1—Specificity foundation model predicting small-molecule drug-target binding from sequence, scored as cross-modal retrieval without docking or assays.
Small molecule16OpennesscrisprSFM
—2—CRISPR off-target prediction model that scores gRNA-DNA specificity from sequence, framing guide-target recognition as cross-modal retrieval.
DNA & Gene19Opennessenzyme-SFM
—2—Enzyme-substrate specificity model that scores catalytic pairs from sequence with a physics-derived dual-encoder and a contrastive objective.
Protein23OpennessmhcSFM
—2—Peptide-MHC binding specificity model that frames presentation as cross-modal retrieval, aligning peptide and MHC encoders by contrastive learning.
Protein23Opennessmir-SFM
—2—Foundation model that predicts microRNA-mRNA target specificity from sequence, using a dual-encoder trained with a symmetric contrastive objective.
RNA25OpennessTESSERA
5——Self-supervised foundation model that embeds cancer genomes from somatic SNVs and copy-number alterations across 33 tumor types for tumor subtyping.
DNA & Gene28OpennessGenBloom
3——Genetically aligned foundation model for blood smear cytology that links single-cell morphology to the chromosomal aberrations behind AML and APL.
Pathology65OpennessC3P
1——Contrastive promoter-protein pretraining that aligns bacterial promoters with their encoded proteins to learn regulatory genomics representations.
DNA & Gene77OpennessMetabolomic foundation model pretrained on UK Biobank NMR metabolite profiles, reused with a frozen backbone for aging, subtyping, and disease risk.
Metabolomics7OpennessBRIDGE
———The University of Hong KongMay 8, 2026contrastive_learningfoundation_modelgene_expression_prediction+8Multi-organ foundation model aligning histology images with spatial-transcriptomics profiles for zero-shot expression and survival prediction.
PathologySpatial omics31OpennessConvergeCELL
——34Virtual cell foundation model pretrained on over 23 million cells from 5,000 patient samples for drug target and biomarker discovery.
Single-cell67OpennessProtSent
7—12Protein sequence embedding model, contrastively fine-tuned from ESM-2, that places functionally and structurally related proteins close together.
Protein87Openness- University of KentuckyMay 4, 2026contrastive_learningintrinsic_disorder_predictionmolecular_dynamics+6
Protein language model aligning ESM sequence embeddings with molecular dynamics trajectories for zero-shot mutation effect and stability prediction.
Protein10Openness H2O
———Tencent AI for Life Science Lab +2 othersApril 24, 2026contrastive_learningfoundation_modelgene_expression+6Pathology foundation model that infers spatial transcriptomics and proteomics directly from routine H&E whole-slide images, with no spatial assay.
PathologySpatial omics7OpennessDIA-CLIP
———AI for Science Institute +1 otherApril 16, 2026contrastive_learningencoder_decoderfoundation_model+6Contrastive dual-encoder model for DIA proteomics, embedding peptides and spectra in a shared space for zero-shot peptide-spectrum matching.
Protein11OpennessCLOP-DiT
———Generates single-cell transcriptomes from structured biological metadata via contrastive language-omics pretraining and a diffusion transformer.
Single-cell10Openness